Glucose transporters in preimplantation development.
نویسندگان
چکیده
The inability of the embryo to utilize glucose as a fuel before compaction has been an area of much speculation. It is suggested that limitations in glucose transporter processes are the prime reasons for this. The recent identification of GLUT3 as the transporter responsible for the uptake of maternal glucose after compaction may provide the missing link in this puzzle. Furthermore, the coincidence of its expression with the onset of embryonic glucose utilization suggests that GLUT3 may be involved in the determination of metabolic priorities of the embryo. A model for the uptake of glucose by the blastocyst based on the function of two facilitative glucose transporters, GLUT3 and GLUT1, is proposed which can accommodate growth factor regulation of embryonic processes and is consistent with both the well established biochemical characteristics of GLUT proteins and the physiology of the embryo.
منابع مشابه
Expression of glucose transporter and glucose uptake in human oocytes and preimplantation embryos.
The expression of glucose transporters 1, 2, 3 and 4 was evaluated in human oocytes and polyploid preimplantation embryos. Only glucose transporter 1 (GLUT-1) isoform was detected in oocytes and in 2-12-cell stage embryos. Glucose uptake was markedly increased in embryos as compared to oocytes (19.7 +/- 3.4 pmol/min/embryo and 2.3 +/- 0.3 pmol/min/oocyte), and GLUT-1 was inhibited by cytochalas...
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The glucose transporter (GLUT) isoforms responsible for glucose uptake in early mouse embryos have been identified. GLUT 1, the isoform present in nearly every tissue examined including adult brain and erythrocytes, is expressed throughout preimplantation development. GLUT 2, which is normally present in adult liver, kidney, intestine and pancreatic beta cells is expressed from the 8-cell stage...
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Background and purpose : Ënergy sources play an important role in preimplantation development. Ëffect of glucose, an importamt energy source, has been studied in different stages of embryo development. Ënergy sources play important role in embryos development in preimplantation peroid. Glucose is one of the main sources of energy supply, and it’s effect has been studied in different stages of...
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ورودعنوان ژورنال:
- Reviews of reproduction
دوره 3 2 شماره
صفحات -
تاریخ انتشار 1998